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KMID : 1094720160210040567
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Biotechnology and Bioprocess Engineering
2016 Volume.21 No. 4 p.567 ~ p.572
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In vivo fluorescence imaging to assess early therapeutic response to tumor progression in a xenograft cancer model
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Kim Eun-Joong
Lee Hyun-Seung
Yeom A-Reum
Hong Kwan-Soo
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Abstract
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Bioimaging technology plays an important role in assessment of therapeutic response in cancer therapy. Here, we report a non-invasive monitoring system for measuring tumor growth by in vivo fluorescence imaging. Target cells for xenograft tumor induction were manipulated by cell-surface fluorescence labelling. Fluorescence was clearly detected in vitro and in vivo without affecting cytotoxicity. Anti-tumor efficacy was evaluated by directly measuring the fluorescence signal of a progressive tumor in a xenograft model. This non-invasive in vivo monitoring system can be used to assess the early response to antitumor therapeutics and may be a valuable tool to replace or complement traditional caliper-based methods for preclinical studies.
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KEYWORD
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cell labelling, fluorescence imaging, therapeutic response monitoring, xenograft tumor mouse
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